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Title: Synthesis and Evaluation of Anti-Lipase Potential and Molecular Docking of N’-(2-Hydroxy-5-Nitrobenzylidene) Naphthalene-2-Sulfonohydrazide
Other Titles: تخليق وتقييم إمكانات مضادات الليباز والالتحام الجزيئي لـلمركب الجديد N '- (2-Hydroxy-5-nitrobenzylidene) naphthalene-2-sulfonohydrazide
Authors: Amereih, Sameer
Daraghmeh, Abd
Warad, Ismail
Al-Nuri, Mohammed
Keywords: Sulfonyl hydrazide Schiff Base;Spectral Characterization;Antimicrobial Activity;Pancreatic Lipase Inhibition;Auto docking
Issue Date: 1-Dec-2020
Publisher: Palestine Technical University -Kadoorie
Citation: Amereih, S. ., Daraghmeh, A., Warad, I., & Al-Nuri, M. (2020). Synthesis and Evaluation of Anti-Lipase Potential and Molecular Docking of N’-(2-Hydroxy-5-nitrobenzylidene) naphthalene-2-sulfonohydrazide. Palestine Technical University Research Journal, 8(2), 01–11.
Series/Report no.: 8(2);01-11
Abstract: N’-(2-Hydroxy-5-nitrobenzylidene) naphthalene-2-sulfonohydrazide (SB) was prepared by condensation reaction, of naphthalene-2-sulfonylchloride with 2-Hydroxy-5-nitrobenzaldehyde. The Schiff base product (SB) was isolated, purified and then spectrally characterized via UV-Vis, FT-IR, 1H and 13C NMR analysis, where strong evidences confirmed the formation of the desired product.Pancreatic porcine lipase inhibition of the Schiff base product was evaluated and compared with thereference “Orlistat”. The product was an active as a lipase enzyme inhibitor with IC50 42.65±0.97 mcg/ml. The molecular docking of the compound with porcine pancreatic lipase was investigating, the results of theoretical docking explained the experimentalone since several hydrogen bonds between the Schiff base compound and amino acids in lipase were detected.Antimicrobial activity of SB product was also evaluated in vitro against several types of bacteria such as: Escherichia coli, Staphylococcus aureus,Pseudomonas aeruginosa, Klebsiella pneumonia and MRSA by Minimum Inhibitory Concentration (MIC) test using tetracycline (TE) as a standard antibiotic. Results showed a bacteriostatic effect of this compound against bacteria such as MRSA, P. aeruginosa andK. pneumoniae.
metadata.dc.identifier.doi: 10.53671
Appears in Collections:2020

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